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1

First Synthetic Carbohydrates with the Full Anticoagulant Properties of Heparin

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Guy Jaurand, Jean-P. Hérault, Jean-C. Lormeau, Constant A. A. van Boeckel, Jean-M. Herbert

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

2

The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

Dr. Constant A. A. van Boeckel, Dr. Maurice Petitou

Journal:

Angewandte Chemie International Edition

Year:

1993

Language:

english

File:

PDF, 2.54 MB

english, 1993

3

Drug Discovery Maps, a machine learning model, visualizes and predicts kinome-inhibitor interaction landscapes

Janssen, Antonius P.A., Grimm, Sebastian H., Wijdeven, Ruud H.M., Lenselink, Eelke B., Neefjes, Jacques, van Boeckel, Constant C.A., van Westen, Gerard J.P., van der Stelt, Mario

Journal:

Journal of Chemical Information and Modeling

Year:

2018

Language:

english

File:

PDF, 7.49 MB

english, 2018

4

Die ersten synthetischen Kohlenhydrate mit den vollständigen antikoagulierenden Eigenschaften von Heparin

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Guy Jaurand, Jean-P. Hérault, Jean-C. Lormeau, Constant A. A. van Boeckel, Jean-M. Herbert

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 215 KB

german, 1998

5

Probing the Heparin−Antithrombin III Interaction Using Synthetic Pentasaccharides Bearing Positively Charged Groups

Jeroen D. C. Codée, Gijsbert A. van der Marel, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

European Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 270 KB

english, 2002

6

Eine synthetische, heparin-ähnliche Verbindung, die Antithrombin III aktiviert, obwohl sie ein offenkettiges Fragment an Stelle der α-L-Idopyranuronsäure enthält

Dr. Constant A. A. van Boeckel, Jan E. M. Basten, Hans Lucas, Sjoerd F. van Aelst

Journal:

Angewandte Chemie

Year:

1988

File:

PDF, 239 KB

1988

7

Doppelte Stereodifferenzierung bei Glycosidverknüpfungen; die Bildung ungleichsinniger (“mismatched”) Donor/Acceptor-Paare, ein bislang unberücksichtigter Faktor zur Beeinflussung des α/β-Verhältnisses bei der Glycosidsynthese

Drs. Nynke M. Spijker, Dr. Constant A. A. van Boeckel

Journal:

Angewandte Chemie

Year:

1991

File:

PDF, 477 KB

1991

8

Kurze Synthese eines biologisch aktiven, Heparin-ähnlichen Pentasaccharids mit pseudo-alternierender Sequenz

Hans Lucas, Jan E. M. Basten, Dr. Peter Konradsson, Dr. Constant A. A. Van Boeckel

Journal:

Angewandte Chemie

Year:

1993

Language:

german

File:

PDF, 341 KB

german, 1993

9

Die charakteristische AT-III-Bindungsregion in Heparin: eine Leitstruktur für neue synthetische Antithrombotica

Dr. Constant A. A. van Boeckel, Dr. Maurice Petitou

Journal:

Angewandte Chemie

Year:

1993

Language:

german

File:

PDF, 2.70 MB

german, 1993

10

Synthese von maßgeschneiderten Glycokonjugaten, die AT-III-vermittelt die Blutgerinnungsfaktoren Xa und Thrombin inhibieren

Dr. Pieter Westerduin, Jan E. M. Basten, Marc A. Broekhoven, Vera de Kimpe, Dr. Will H. A. Kuijpers, Dr. Constant A. A. van Boeckel

Journal:

Angewandte Chemie

Year:

1996

File:

PDF, 497 KB

1996

11

Ein synthetisches Antithrombin III bindendes Pentasaccharid ist jetzt ein Wirkstoff! Was kommt danach?

Maurice Petitou, Constant A. A. van Boeckel

Journal:

Angewandte Chemie

Year:

2004

Language:

german

File:

PDF, 643 KB

german, 2004

12

Jacques van Boom (1937–2004): Biopolymere

Constant A. A. van Boeckel

Journal:

Angewandte Chemie

Year:

2004

Language:

german

File:

PDF, 145 KB

german, 2004

13

A Synthetic Heparin-like Compound which still Activates Antithrombin III although It Contains an Open Chain Fragment instead of α-L-Idopyranuronate

Dr. Constant A. A. van Boeckel, Jan E. M. Basten, Hans Lucas, Sjoerd F. van Aelst

Journal:

Angewandte Chemie International Edition

Year:

1988

Language:

english

File:

PDF, 257 KB

english, 1988

14

Double Stereodifferentiation in Carbohydrate Coupling Reactions: The Mismatched Interaction of Donor and Acceptor as an Unprecedented Factor Governing the α/β Ratio of Glycoside Formation

Drs. Nynke M. Spijker, Dr. Constant A. A. van Boeckel

Journal:

Angewandte Chemie International Edition

Year:

1991

Language:

english

File:

PDF, 455 KB

english, 1991

15

A Short Synthetic Route towards a Biologically Active Heparin-like Pentasaccharide with a Pseudo-Alternating Sequence

Hans Lucas, Jan E. M. Basten, Dr. Peter Konradsson, Dr. Constant A. A. van Boeckel

Journal:

Angewandte Chemie International Edition

Year:

1993

Language:

english

File:

PDF, 383 KB

english, 1993

16

Synthesis of Tailor-Made Glycoconjugates Showing AT III-Mediated Inhibition of Blood Coagulation Factors Xa and Thrombin

Dr. Pieter Westerduin, Jan E. M. Basten, Marc A. Broekhoven, Vera de Kimpe, Dr. Ir. Will H. A. Kuijpers, Prof. Dr. Constant A. A. van Boeckel

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 330 KB

english, 1996

17

A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Maurice Petitou, Constant A. A. van Boeckel

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 628 KB

english, 2004

18

Jacques van Boom (1937–2004): Biopolymers

Constant A. A. van Boeckel

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

19

Surface Plasmon Resonance Evaluation of Various Aminoglycoside–RNA Hairpin Interactions Reveals Low Degree of Selectivity

Steven H. L. Verhelst, Paul J. A. Michiels, Gijsbert A. van der Marel, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

2004

Language:

english

File:

PDF, 173 KB

english, 2004

20

Synthesis of a Conformationally Constrained Heparin-like Pentasaccharide

Prof. Dr. Jacques H. van Boom, Dr. Nobuo Sakairi, Dr. Gijsbert A. van Der Marel, Jan E. M. Basten, Constant A. A. van Boeckel

Journal:

Chemistry - A European Journal

Year:

1996

Language:

english

File:

PDF, 868 KB

english, 1996

21

Synthesis of a Pentasaccharide–Oligonucleotide Conjugate: A Novel Antithrombotic Agent

Rogier C. Buijsman, Dr. Ir. Will H. A. Kuijpers, Jan E. M. Basten, Dr. Esther Kuyl-Yeheskiely, Dr. Gijsbert A. van der Marel, Prof. Dr. Constant A. A. van Boeckel, Prof. Dr. Jacques H. van Boom

Journal:

Chemistry - A European Journal

Year:

1996

Language:

english

File:

PDF, 673 KB

english, 1996

22

ChemInform Abstract: First Synthetic Carbohydrates with the Full Anticoagulant Properties of Heparin.

Maurice Petitou, Philippe Duchaussoy, Pierre-A. Driguez, Guy Jaurand, Jean-P. Herault, Jean-C. Lormeau, Constant A. A. van Boeckel, Jean-M. Herbert

Journal:

Year:

1999

File:

PDF, 26 KB

1999

23

ChemInform Abstract: Design and Synthesis of a Novel Synthetic NAPAP-Pentasaccharide Conjugate Displaying a Dual Antithrombotic Action.

Rogier C. Buijsman, Jan E. M. Basten, Theo G. van Dinther, Gijbert A. van der Marel, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

1999

File:

PDF, 25 KB

1999

24

ChemInform Abstract: Montmorillonite K-10 Clay Assisted Transformation of Vinylketoses into Spirochromans and Arylketoses.

Peter A. V. van Hooft, Paul F. van Swieten, Gijsbert A. van der Marel, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

2001

File:

PDF, 30 KB

2001

25

ChemInform Abstract: Stereoselective Transformations on D-Glucose-Derived Eight-Membered Ring Carbocycles.

Peter A. V. van Hooft, Remy E. J. N. Litjens, Gijsbert A. van der Marel, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

2001

File:

PDF, 34 KB

2001

26

A Stereoselective Route Towards Highly Functionalized 4,6-Diaminocyclohexene Derivatives.

Steven H. L. Verhelst, Wouter Wiedenhof, Huib Ovaa, Gijsbert A. van der Harel, Herman S. Overkleeft, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

2002

File:

PDF, 34 KB

2002

27

Chemoselective Glycosylations Using Sulfonium Triflate Activator Systems.

Jeroen D. C. Codee, Leendert J. van den Bos, Remy E. J. N. Litjens, Herman S. Overkleeft, Constant A. A. van Boeckel, Jacques H. van Boom, Gijs A. van der Marel

Journal:

Year:

2004

Language:

english

File:

PDF, 178 KB

english, 2004

28

Synthesis of Orthogonally Protected 2-Deoxystreptamine Stereoisomers.

Steven H. L. Verhelst, Tom Wennekes, Gijsbert A. van der Marel, Herman S. Overkleeft, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

2004

File:

PDF, 235 KB

2004

29

A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?

Maurice Petitou, Constant A. A. van Boeckel

Journal:

Year:

2004

File:

PDF, 52 KB

2004

30

Glycosylation of Cyclitols: Synthesis of Neamine-Type Aminoglycosides.

Steven H. L. Verhelst, Lisette Magnee, Tom Wennekes, Wouter Wiedenhof, Gijsbert A. van der Marel, Herman S. Overkleeft, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

Year:

2004

File:

PDF, 205 KB

2004

31

A Modular Strategy Toward the Synthesis of Heparin-Like Oligosaccharides Using Monomeric Building Blocks in a Sequential Glycosylation Strategy.

Jeroen D. C. Codee, Bas Stubba, Marialuisa Schiattarella, Herman S. Overkleeft, Constant A. A. van Boeckel, Jacques H. van Boom, Gijsbert A. van der Marel

Journal:

Year:

2005

File:

PDF, 8 KB

2005

32

The Synthesis of Well-Defined Heparin and Heparan Sulfate Fragments

Jeroen D. C. Codee, Herman S. Overkleeft, Gijsbert A. van der Marel, Constant A. A. van Boeckel

Journal:

Year:

2005

File:

PDF, 8 KB

2005

33

Glycosylation of Cyclitols: Synthesis of Neamine-Type Aminoglycosides

Steven H. L. Verhelst, Lisette Magnée, Tom Wennekes, Wouter Wiedenhof, Gijsbert A. van der Marel, Herman S. Overkleeft, Constant A. A. van Boeckel, Jacques H. van Boom

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 154 KB

english, 2004

34

Konformationsanalyse, XXVIII. Konformationsanalyse von Heparin-analogen Di- und Trisacchariden mit α-L-Idopyranose-Einheiten

Hans Paulsen, Annette Pollex, Volker Sinnwell, Constant A. A. van Boeckel

Journal:

European Journal of Organic Chemistry

Year:

1988

File:

PDF, 792 KB

1988

35

Synthese von Heparin-verwandten Trisacchariden mit einer zentralen α-L-Idopyranose-Einheit

Hans Paulsen, Axel Huffziger, Constant A. A. van Boeckel

Journal:

European Journal of Organic Chemistry

Year:

1988

File:

PDF, 984 KB

1988

36

Synthesis of a lipoteichoic acid-carrier fragment of Staphylococcus aureus

Jan J. Oltvoort, Marcel Kloosterman, Constant A.A. van Boeckel, Jacques H. van Boom

Journal:

Carbohydrate Research

Year:

1984

Language:

english

File:

PDF, 1.51 MB

english, 1984

37

Synthesis of a novel carbamate-glucuronide

Frans M. Kaspersen, Constant A.A. van Boeckel, Leon P.C. Delbressine, Annemiek Koten, Peter L. Jacobs, Carel W. Funke

Journal:

Carbohydrate Research

Year:

1989

Language:

english

File:

PDF, 166 KB

english, 1989

38

Synthesis of a hexasaccharide corresponding to a porcine zona pellucida fragment that inhibits porcine sperm-oocyte interaction in vitro

Nynke M. Spijker, Cor A. Keuning, Mariska Hooglugt, Gerrit H. Veeneman, Constant A.A. van Boeckel

Journal:

Year:

1996

Language:

english

File:

PDF, 993 KB

english, 1996

39

Chemoselective glycosylations using sulfonium triflate activator systems

Jeroen D.C Codée, Leendert J van den Bos, Remy E.J.N Litjens, Herman S Overkleeft, Constant A.A van Boeckel, Jacques H van Boom, Gijs A van der Marel

Journal:

Year:

2004

Language:

english

File:

PDF, 290 KB

english, 2004

40

Synthesis of orthogonally protected 2-deoxystreptamine stereoisomers

Steven H.L Verhelst, Tom Wennekes, Gijsbert A van der Marel, Herman S Overkleeft, Constant A.A van Boeckel, Jacques H van Boom

Journal:

Year:

2004

Language:

english

File:

PDF, 279 KB

english, 2004

41

Synthesis of a pentasaccharide and a heptasaccharide corresponding to an ovarian glycoprotein; studies towards glycosylations

Nynke M. Spijker, Pieter Westerduin, Constant A.A. van Boeckel

Journal:

Year:

1992

Language:

english

File:

PDF, 1.80 MB

english, 1992

42

Triisobutylaluminium mediated carbocyclisation of sugar derived spiroketals and ketosides

Peter A.V van Hooft, Gijsbert A van der Marel, Constant A.A van Boeckel, Jacques H van Boom

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 95 KB

english, 2001

43

Synthesis of 1,4,5-trissulphated and 1,4,5-trissulphamoylated myo-inositols: Isosteric myo-inositol 1,4,5-trisphosphate analogues

Pieter Westerduin, Henrica A.M. Willems, Constant A.A. van Boeckel

Journal:

Tetrahedron Letters

Year:

1990

File:

PDF, 155 KB

1990

44

Total synthesis of new 1,5-bissubstituted myo-inositol derivatives. Synthesis of D-myo-inositol 1,5-bisphosphate, 3,5-bisphosphate and of rac. 1,5-Bissulphated and 1,5-bissulphamoylated isosteric analogues

Pieter Westerduin, Henrica A.M. Willems, Constant A.A. van Boeckel

Journal:

Tetrahedron Letters

Year:

1990

File:

PDF, 209 KB

1990

45

A stereoselective route towards highly functionalized 4,6-diaminocyclohexene derivatives

Steven H.L. Verhelst, Wouter Wiedenhof, Huib Ovaa, Gijsbert A. van der Marel, Herman S. Overkleeft, Constant A.A. van Boeckel, Jacques H. van Boom

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 231 KB

english, 2002

46

A novel and flexible synthesis of pyranose spiroacetal derivatives

Peter A.V. van Hooft, Michiel A. Leeuwenburgh, Herman S. Overkleeft, Gijsbert A. van der Marel, Constant A.A. van Boeckel, Jacques H. van Boom

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 213 KB

english, 1998

47

Design and synthesis of a possible mimic of a thrombin-binding DNA aptamer

Rogier C. Buijsman, Jeroen W.J. Schipperijn, Esther Kuyl-Yeheskiely, Gijs A. van der Marel, Constant A.A. van Boeckel, Jacques H. van Boom

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 296 KB

english, 1997

48

Design and synthesis of a novel synthetic NAPAP-penta-saccharide conjugate displaying a dual antithrombotic action

Rogier C. Buijsman, Jan E.M. Basten, Theo G. van Dinther, Gijsbert A. van der Marel, Constant A.A. van Boeckel, Jacques H. van Boom

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 287 KB

english, 1999

49

Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains

Rogier C. Buijsman, Jan E.M. Basten, Cornelia M. Dreef-Tromp, Gijsbert A. van der Marel, Constant A.A. van Boeckel, Jacques H. van Boom

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 368 KB

english, 1999

50

Unexpected phenomena in glycosylations of acceptors with L-idose configuration

Nynke M. Spijker, Jan E. M. Basten, Constant A. A. van Boeckel

Journal:

Recueil des Travaux Chimiques des Pays-Bas

Year:

1993

Language:

english

File:

PDF, 629 KB

english, 1993

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